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KMID : 1007520110200010255
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Food Science and Biotechnology
2011 Volume.20 No. 1 p.255 ~ p.259
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Ameliorating Effects of a Nopal (Opuntia ficus-indica) Complex on Blood Glucose in db/db Mice
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Yoon Jin-A
Lee Sung-Joon
Kim Han-Kyeom
Son Yong-Suk
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Abstract
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This study investigated the effects of a nopal (Opuntia ficus-indica) complex (OF) on blood glucose metabolism in db/db mice for 4 weeks. Food and water intake significantly decreased in OF-treated mice compared to controls (p<0.05). In addition, blood glucose and plasma insulin levels were significantly reduced in the OF-treated group compared to the controls (p<0.05). Histopathological analysis showed that the morphology of pancreatic islets was improved in the OF-treated db/db mice. Immunohistochemistry of the pancreatic islets showed that insulin production and the number of β-cells apparently increased.
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KEYWORD
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Opuntia ficus-indica, hypoglycemic, insulin, pancreatic islet, db/db mice
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